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Dr. Muhammad Irfan

Government College University, Pakistan.

Dr. Muhammad Irfan

Government College University, Pakistan.

Title: Effect of polar protic solvents on the physicochemical properties and dissolution of soluplus based solid dispersions of Rosuvastatin calcium


Summary

Solid dispersions (SD) is a promising technology for improving dissolution and thereby bioavailability of poorly soluble drugs. This study aimed to prepare SD of Rosuvastatin calcium, a BCS class II drug, through solvent evaporation method using variable ratios of soluplus to achieve the objective of boosted solubility. Moreover, impact of polar protic solvents (acetone, MeOH and AC:MeOH) was also investigated to foresee the transformation of physicochemical properties. The prepared formulations were assessed for saturation solubility, in-vitro drug release, FTIR, XRD, DSC and SEM analysis. The results revealed that all SDs profoundly increased solubility as well as drug release. Among the optimized SD formulations, RSEB-10 with a remarkable increase of 34.95 fold in solubility presented 81.67% of drug release within 5 minutes in contrast to only 25% release of pure RoCa. Importantly, the role of solvent, though present in minute amounts after evaporation, could not be underrated and the combination of polar solvents noticeably influenced in potentiating the solubility of RoCa.