Title: Combination of Simvastatin and Patchouli oil in a hydrogel film for Wound Healing Appliction
SUMMARY
The treatment of chronic wounds remains a global challenge,
imposing a growing financial burden on patients and hospitals, more possibly
due to oxidative stress, over expressed inflammatory response and persistent
infection during healing process. Therefore developing more efficient and easy
to use dressing materials with adequate mechanical strength, considerable water
vapor transmission rate, sufficient antibacterial, antioxidant and
anti-inflammatory properties is on demand for clinical application. Herein, we
designed a bioactive hydrogel dressing by co-encapsulating Simvastatin (SVT)
and Patchouli oil (PO) in a film matrix through ionotropic gelation method.
Developed composites displayed excellent mechanical strength (tensile strength
of 24.12 to 26.13 MPa), High Swelling rate (3329 to 2780 % at 72 hours), and
excellent water vapor transmission rate (1708.33-2134.33g/m2/day). Solid state
characterization of prepared films revealed successful incorporation of SVT and
PO without any perceptible interactions. Films were found to maintain sustained
delivery of SVT and PO. Superior anti-oxidant (60 to 73%), anti-inflammatory
(53 to 67%), and anti-bacterial activity against gram-positive and
gram-negative bacteria were noted. The current approach validates that SVT-PO
combination in hydrogel films could be utilized for wound healing.